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KMID : 0043320120350040739
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Archives of Pharmacal Research
2012 Volume.35 No. 4 p.739 ~ p.746
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Anti-inflammatory Effects of Amomum compactum on RAW 264.7 cells via induction of heme oxygenase-1
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Lee Jin-Ah
Lee Mee-Young
Shin In-Sik
Seo Chang-Seob
Ha Hye-Kyung
Shin Hyeun-Kyoo
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Abstract
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Amomum compactum is commonly used in Korean traditional medicine. In this study, we demonstrate that A. compactum ethanolic extract (ACEE) has anti-inflammatory effects in a lipopolysaccharide-induced RAW 264.7 cell model of inflammation. In this system, ACEE prominently inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and inhibited the protein expression of inducible nitric oxide synthase and cyclooxygenase-2. Furthermore, ACEE treatment inhibited the translocation of nuclear factor-kappaB (NF-κB) and the degradation of inhibitory factor-kappaB alpha, but enhanced the expression of heme oxygenase (HO)-1 and the nuclear translocation of nuclear factor-erythroid 2 (Nrf2). Treatment with tin protoporphyrin IX dichloride (SnPP), a selective HO-1 inhibitor, reversed the ACEE-induced suppression of NO production, suggesting that the induction of HO-1 is involved in the suppression of NO, TNF-α, and IL-6 production by ACEE. Taken together, these results suggest that ACEE have anti-inflammatory effects occurring through HO-1 induction, which leads to suppression of the blocking NF-κB.
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KEYWORD
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Anti-inflammatory, Amomum compactum, Heme oxygenase-1, Nrf2
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